Effect of l-arginine on life quality in patients with hypertensive disease and chronic obstructive pulmonary disease

The aim: of the research was to improve the effectiveness of pharmacotherapy for patients with hypertensive disease and co-existent chronic obstructive pulmonary disease using an exogenous nitric oxide donor - L-arginine through the correction of structural and functional indices of the heart, pulmonary ventilation and according to patients’ life quality. Materials and Methods: The study included 102 patients with stage II second-degree/third-degree hypertensive disease; among them, there were 82 patients with hypertensive disease and co-existent chronic obstructive pulmonary disease and 20 patients with hypertensive disease (essential hypertension) of a similar stage and degree at the age of 65.5±4.12 years. According to treatment, 82 patients with hypertensive disease and chronic obstructive pulmonary disease were divided into two homogeneous groups according to age, sex, duration of hypertensive disease and chronic obstructive pulmonary disease. Group I (the control group) included 40 patients undergoing basic therapy only. Group II (the main group) included 42 patients, who, in addition to basic therapy, received L-arginine. Results and Discussion: There was noted a precipitating effect of chronic obstructive pulmonary disease on the clinical course of hypertensive disease through the worsening of the indicators of the cardiorespiratory system. In patients with hypertensive disease and co-existent chronic obstructive pulmonary disease, the left ventricle was characterized by an increase in metric and volumetric indices - end-systolic dimensionincreased by 17.8%, end-systolic volume increased by 44.4% compared to patients with isolated hypertensive disease (p