Inside Cover: One-Pot Biocatalytic Double Oxidation of [alpha]-Isophorone for the Synthesis of Ketoisophorone

The Cover shows the chemical structure of ketoisophorone (KIP), a valuable building block of vitamins, pharmaceuticals and APIs. In their Full Paper, M. Tavanti etal. describe the first biocatalytic cascade to access this key intermediate through the double allylic oxidation of the readily available [alpha]-isophorone employing a variant of P450cam-RhFRed and Cm-ADH10. The designed cascade has been demonstrated both as a one-pot two-step process and as a cascade process employing designer cells co-expressing the two biocatalysts, with a productivity of up to 1.4gL-1d-1. More information can be found in the Full Paper by M. Tavanti etal. on page3338 in Issue 17, 2017 (DOI: 10.1002/cctc.201700620).