Emerging applications of adaptive optics retinal imaging

Summary Adaptive optics (AO) is an optical technology used in astrophysics to compensate the turbulences of the atmosphere which alter the quality of the images. That principle has been applied to various image modalities (OCT, SLO, Flood, etc) permitting the observation of the retina's finest structures at the microscopic scale. The rtx1 is the first, and until now, the only compact AO retinal imaging medical device available on the market. Based on an en‐face near infrared imaging approach, the rtx1 allows to observe the cone photoreceptors mosaic, the lumen and the walls of the retinal arterioles, and the pores of the lamina cribrosa. It is now possible to detect the early signs of diseases and to follow‐up the effect of a treatment. Thanks to its ergonomy for the patient and the user, the rtx1 is more and more adopted by clinical research centers worldwide to investigate various medical fields. We will present here recent results in the field of ophthalmology but also in translational research using AO retinal imaging to investigate pathologies in cardio‐vascular and neurological diseases.