Interest of analysis of circumpapillary retinal nerve fibers layer thickness at different measurement diameters
Purpose The analysis of the circumpapillary retinal nerve fiber layer (RNFL) is a major data in structural analysis in glaucoma. Since OCT development, analysis is on a circle of 3.4 mm diameter. This study evaluates the diagnostic capability of an RNFL analysis with different diameter measurements....
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2017-09, Vol.95 (S259), p.n/a |
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| creator | El Chehab, H. Agard, E. Loria, O. Théo, L. Dot, C. |
| description | Purpose
The analysis of the circumpapillary retinal nerve fiber layer (RNFL) is a major data in structural analysis in glaucoma. Since OCT development, analysis is on a circle of 3.4 mm diameter. This study evaluates the diagnostic capability of an RNFL analysis with different diameter measurements.
Methods
60 glaucomatous and 58 control patients had a complete ophthalmological exam to exclude patients with papillary morphological abnormalities (coloboma, dysversion …). Others had an OCT Spectralis (Heidelberg Engineering, Germany) of RNFL on 4 circles of different diameters: 3.4, 3.5, 4.1 and 4.7 mm. Only one eye per patient was randomly included. The diagnostic capabability of each of these circles was analyzed for global mean thickness and for each sector (temporal, temporal‐superior, nasal‐superior, nasal, nasal‐inferior and temporal‐inferior) by calculating areas under ROC curve (AUROC).
Results
Patients were comparable for clinical characteristics. In glaucomatous patient group, 58.9% of the patients were early glaucoma (MD> ‐6 dB) and 21.4% of the patients were severe (MD |
| doi_str_mv | 10.1111/j.1755-3768.2017.01125 |
| format | Article |
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The analysis of the circumpapillary retinal nerve fiber layer (RNFL) is a major data in structural analysis in glaucoma. Since OCT development, analysis is on a circle of 3.4 mm diameter. This study evaluates the diagnostic capability of an RNFL analysis with different diameter measurements.
Methods
60 glaucomatous and 58 control patients had a complete ophthalmological exam to exclude patients with papillary morphological abnormalities (coloboma, dysversion …). Others had an OCT Spectralis (Heidelberg Engineering, Germany) of RNFL on 4 circles of different diameters: 3.4, 3.5, 4.1 and 4.7 mm. Only one eye per patient was randomly included. The diagnostic capabability of each of these circles was analyzed for global mean thickness and for each sector (temporal, temporal‐superior, nasal‐superior, nasal, nasal‐inferior and temporal‐inferior) by calculating areas under ROC curve (AUROC).
Results
Patients were comparable for clinical characteristics. In glaucomatous patient group, 58.9% of the patients were early glaucoma (MD> ‐6 dB) and 21.4% of the patients were severe (MD <‐12 dB). For conventional RNFL measurement (3.4 mm), the temporal‐inferior sector had the highest diagnostic capability with an AUROC of 0.916. For the 3.5 mm measurement, the global mean thickness of the RNFL had the highest diagnostic capability (AUROC = 0.909). For the 4.1 mm measurement, the global mean thickness of the RNFL had the highest diagnostic capability (AUROC = 0.915). For the 4.7 mm measurement, the average thickness of the temporal‐inferior sector had the highest diagnostic capability (AUROC = 0.909). There was no statistically significant difference between these 4 AUROC.
Conclusions
Regardless of the diameter of RNFL analysis, the diagnostic capability remains very good with no significant difference in patients with normal papillary morphology.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2017.01125</identifier><language>eng</language><publisher>Malden: Wiley Subscription Services, Inc</publisher><subject>Data processing ; Eye ; Fibers ; Glaucoma ; Measurement methods ; Open systems ; Patients ; Retina ; Statistical analysis ; Structural analysis</subject><ispartof>Acta ophthalmologica (Oxford, England), 2017-09, Vol.95 (S259), p.n/a</ispartof><rights>2017 The Authors Acta Ophthalmologica © 2017 Acta Ophthalmologica Scandinavica Foundation</rights><rights>Copyright © 2017 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1755-3768.2017.01125$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45554,46812</link.rule.ids></links><search><creatorcontrib>El Chehab, H.</creatorcontrib><creatorcontrib>Agard, E.</creatorcontrib><creatorcontrib>Loria, O.</creatorcontrib><creatorcontrib>Théo, L.</creatorcontrib><creatorcontrib>Dot, C.</creatorcontrib><title>Interest of analysis of circumpapillary retinal nerve fibers layer thickness at different measurement diameters</title><title>Acta ophthalmologica (Oxford, England)</title><description>Purpose
The analysis of the circumpapillary retinal nerve fiber layer (RNFL) is a major data in structural analysis in glaucoma. Since OCT development, analysis is on a circle of 3.4 mm diameter. This study evaluates the diagnostic capability of an RNFL analysis with different diameter measurements.
Methods
60 glaucomatous and 58 control patients had a complete ophthalmological exam to exclude patients with papillary morphological abnormalities (coloboma, dysversion …). Others had an OCT Spectralis (Heidelberg Engineering, Germany) of RNFL on 4 circles of different diameters: 3.4, 3.5, 4.1 and 4.7 mm. Only one eye per patient was randomly included. The diagnostic capabability of each of these circles was analyzed for global mean thickness and for each sector (temporal, temporal‐superior, nasal‐superior, nasal, nasal‐inferior and temporal‐inferior) by calculating areas under ROC curve (AUROC).
Results
Patients were comparable for clinical characteristics. In glaucomatous patient group, 58.9% of the patients were early glaucoma (MD> ‐6 dB) and 21.4% of the patients were severe (MD <‐12 dB). For conventional RNFL measurement (3.4 mm), the temporal‐inferior sector had the highest diagnostic capability with an AUROC of 0.916. For the 3.5 mm measurement, the global mean thickness of the RNFL had the highest diagnostic capability (AUROC = 0.909). For the 4.1 mm measurement, the global mean thickness of the RNFL had the highest diagnostic capability (AUROC = 0.915). For the 4.7 mm measurement, the average thickness of the temporal‐inferior sector had the highest diagnostic capability (AUROC = 0.909). There was no statistically significant difference between these 4 AUROC.
Conclusions
Regardless of the diameter of RNFL analysis, the diagnostic capability remains very good with no significant difference in patients with normal papillary morphology.</description><subject>Data processing</subject><subject>Eye</subject><subject>Fibers</subject><subject>Glaucoma</subject><subject>Measurement methods</subject><subject>Open systems</subject><subject>Patients</subject><subject>Retina</subject><subject>Statistical analysis</subject><subject>Structural analysis</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkFtLxDAQhYMouK7-BQn43Jr0kjbgy7J4WVjYBxV8C2k6wdTeTFql_97Uyj6blxxm5sxwPoSuKQmpf7dVSLM0DeKM5WFEaBYSSqP0BK2O5dOjTt_O0YVzFSGMMpasULdrB7DgBtxpLFtZT864WStj1dj0sjd1Le2ELQzGt3EL9guwNgVYh2s5gcXDu1EfLTiH5YBLo7Vf2A64AelGC82sSyMb8IfcJTrTsnZw9fev0evD_cv2KdgfHnfbzT5QNGNpoHOuCiJjxiEqUsUyVuqyKHWcSUUTqiHWMaelypIoKzgnEaU8l1AqBaBSyeM1uln29rb7HH0-UXWj9QGcoDxmUcRzlvgptkwp2zlnQYvemsbHFZSIGa6oxExOzBTFDFf8wvXGu8X4bWqY_ukSm8PzYv8BVImCNg</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>El Chehab, H.</creator><creator>Agard, E.</creator><creator>Loria, O.</creator><creator>Théo, L.</creator><creator>Dot, C.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>201709</creationdate><title>Interest of analysis of circumpapillary retinal nerve fibers layer thickness at different measurement diameters</title><author>El Chehab, H. ; Agard, E. ; Loria, O. ; Théo, L. ; Dot, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1765-f89cb0a369e2b5c676dfdbdf37ac141fe3f391dc7427b99021198aedcceec5a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Data processing</topic><topic>Eye</topic><topic>Fibers</topic><topic>Glaucoma</topic><topic>Measurement methods</topic><topic>Open systems</topic><topic>Patients</topic><topic>Retina</topic><topic>Statistical analysis</topic><topic>Structural analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Chehab, H.</creatorcontrib><creatorcontrib>Agard, E.</creatorcontrib><creatorcontrib>Loria, O.</creatorcontrib><creatorcontrib>Théo, L.</creatorcontrib><creatorcontrib>Dot, C.</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Chehab, H.</au><au>Agard, E.</au><au>Loria, O.</au><au>Théo, L.</au><au>Dot, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interest of analysis of circumpapillary retinal nerve fibers layer thickness at different measurement diameters</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><date>2017-09</date><risdate>2017</risdate><volume>95</volume><issue>S259</issue><epage>n/a</epage><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
The analysis of the circumpapillary retinal nerve fiber layer (RNFL) is a major data in structural analysis in glaucoma. Since OCT development, analysis is on a circle of 3.4 mm diameter. This study evaluates the diagnostic capability of an RNFL analysis with different diameter measurements.
Methods
60 glaucomatous and 58 control patients had a complete ophthalmological exam to exclude patients with papillary morphological abnormalities (coloboma, dysversion …). Others had an OCT Spectralis (Heidelberg Engineering, Germany) of RNFL on 4 circles of different diameters: 3.4, 3.5, 4.1 and 4.7 mm. Only one eye per patient was randomly included. The diagnostic capabability of each of these circles was analyzed for global mean thickness and for each sector (temporal, temporal‐superior, nasal‐superior, nasal, nasal‐inferior and temporal‐inferior) by calculating areas under ROC curve (AUROC).
Results
Patients were comparable for clinical characteristics. In glaucomatous patient group, 58.9% of the patients were early glaucoma (MD> ‐6 dB) and 21.4% of the patients were severe (MD <‐12 dB). For conventional RNFL measurement (3.4 mm), the temporal‐inferior sector had the highest diagnostic capability with an AUROC of 0.916. For the 3.5 mm measurement, the global mean thickness of the RNFL had the highest diagnostic capability (AUROC = 0.909). For the 4.1 mm measurement, the global mean thickness of the RNFL had the highest diagnostic capability (AUROC = 0.915). For the 4.7 mm measurement, the average thickness of the temporal‐inferior sector had the highest diagnostic capability (AUROC = 0.909). There was no statistically significant difference between these 4 AUROC.
Conclusions
Regardless of the diameter of RNFL analysis, the diagnostic capability remains very good with no significant difference in patients with normal papillary morphology.</abstract><cop>Malden</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/j.1755-3768.2017.01125</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete; Wiley Free Content |
| subjects | Data processing Eye Fibers Glaucoma Measurement methods Open systems Patients Retina Statistical analysis Structural analysis |
| title | Interest of analysis of circumpapillary retinal nerve fibers layer thickness at different measurement diameters |
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