Interest of analysis of circumpapillary retinal nerve fibers layer thickness at different measurement diameters

Purpose The analysis of the circumpapillary retinal nerve fiber layer (RNFL) is a major data in structural analysis in glaucoma. Since OCT development, analysis is on a circle of 3.4 mm diameter. This study evaluates the diagnostic capability of an RNFL analysis with different diameter measurements. Methods 60 glaucomatous and 58 control patients had a complete ophthalmological exam to exclude patients with papillary morphological abnormalities (coloboma, dysversion …). Others had an OCT Spectralis (Heidelberg Engineering, Germany) of RNFL on 4 circles of different diameters: 3.4, 3.5, 4.1 and 4.7 mm. Only one eye per patient was randomly included. The diagnostic capabability of each of these circles was analyzed for global mean thickness and for each sector (temporal, temporal‐superior, nasal‐superior, nasal, nasal‐inferior and temporal‐inferior) by calculating areas under ROC curve (AUROC). Results Patients were comparable for clinical characteristics. In glaucomatous patient group, 58.9% of the patients were early glaucoma (MD> ‐6 dB) and 21.4% of the patients were severe (MD