Hyperpigmented plaque on the sole

Cutaneous examination revealed a black scaly well-circumscribed plaque over lateral margin of the sole of right foot extending to the plantar aspect of the fourth digit (maximum diameter 5 cm). The frequency of BRAF mutation in ALM is lower than other types of melanoma; hence, the therapeutic targets may be different, although there are suggestions that ALM is also likely to be a target of BRAF (B-rapidly accelerated fibrosarcoma) kinase inhibitors due to the constitutively activated RAS (rat sarcoma)/RAF (rapidly accelerated fibrosarcoma)/MEK (mitogen activated protein kinase)/ERK (extracellular signal regulated kinase) pathways. [...]clinicians should remain vigilant in the suspicion of cases for timely management.