Forensic Aspects of Homicides by Insulin Overdose
Highlights • This article is about research consisted of 4 actual homicidal insulin overdose cases. • In acute overdose, neuropathologic changes are not as typical as in previous hypoglycemic studies. • Severe reactive astrocyte proliferation with GFAP IHC is conspicuously found in brains of insulin...
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| Veröffentlicht in: | Forensic science international 2017-09, Vol.278, p.9-15 |
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| creator | Tong, Fang Wu, Rongqi Huang, Wen Yang, Yi Zhang, Lin Zhang, Biao Chen, Xin Tang, Xiaohui Zhou, Yiwu |
| description | Highlights • This article is about research consisted of 4 actual homicidal insulin overdose cases. • In acute overdose, neuropathologic changes are not as typical as in previous hypoglycemic studies. • Severe reactive astrocyte proliferation with GFAP IHC is conspicuously found in brains of insulin overdose. • Presence of insulin and protamine at the injection sites is of forensic significance. |
| doi_str_mv | 10.1016/j.forsciint.2017.06.015 |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 1, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-edc4bd732cc6297e561365018ba15a839cc86ab6412400d823cf4fcb8b27bcbe3</citedby><cites>FETCH-LOGICAL-c520t-edc4bd732cc6297e561365018ba15a839cc86ab6412400d823cf4fcb8b27bcbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0379073817302220$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28686962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tong, Fang</creatorcontrib><creatorcontrib>Wu, Rongqi</creatorcontrib><creatorcontrib>Huang, Wen</creatorcontrib><creatorcontrib>Yang, Yi</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Zhang, Biao</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Tang, Xiaohui</creatorcontrib><creatorcontrib>Zhou, Yiwu</creatorcontrib><title>Forensic Aspects of Homicides by Insulin Overdose</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>Highlights • This article is about research consisted of 4 actual homicidal insulin overdose cases. • In acute overdose, neuropathologic changes are not as typical as in previous hypoglycemic studies. • Severe reactive astrocyte proliferation with GFAP IHC is conspicuously found in brains of insulin overdose. • Presence of insulin and protamine at the injection sites is of forensic significance.</description><subject>Adipocytes</subject><subject>Adult</subject><subject>Aged, 80 and over</subject><subject>Astrocytes</subject><subject>Astrocytes - pathology</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brain damage</subject><subject>Brain stem</subject><subject>Case-Control Studies</subject><subject>Cell Proliferation</subject><subject>Cerebellum</subject><subject>Cerebrum</subject><subject>Clinical medicine</subject><subject>Coma</subject><subject>Corpus callosum</subject><subject>Drug Overdose</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Forensic pathology</subject><subject>Forensic science</subject><subject>Forensic sciences</subject><subject>Gangrene</subject><subject>GFAP</subject><subject>Homicide</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - poisoning</subject><subject>Immunoassay</subject><subject>Immunofluorescence</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Injection</subject><subject>Injections</subject><subject>Insulin</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - poisoning</subject><subject>Insulin overdose</subject><subject>Kidney - pathology</subject><subject>Liver - pathology</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardium - pathology</subject><subject>Overdose</subject><subject>Pathology</subject><subject>Peptides</subject><subject>Peripheral nerves</subject><subject>Protamine</subject><subject>Protamine sulfate</subject><subject>Protamines - metabolism</subject><subject>Skin</subject><subject>Skin - metabolism</subject><subject>Soft tissues</subject><subject>Statistical analysis</subject><subject>Substantia alba</subject><subject>Suicides & suicide attempts</subject><subject>Tissues</subject><subject>Traumatic brain injury</subject><issn>0379-0738</issn><issn>1872-6283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUFrGzEQhUVpaZykfyFd6Hk3o5FX0l4CJjRNIJBDmrNYzc6CHHvlSnbA_74yTlPIKae5vHmP9z0hvktoJEh9uWzGmDKFMG0bBGka0A3I9pOYSWuw1mjVZzEDZboajLIn4jTnJQC0Leqv4gSttrrTOBPyJiaecqBqkTdM21zFsbqN60Bh4Fz5fXU35d0qTNXDC6chZj4XX8Z-lfnb6z0TTzc_f1_f1vcPv-6uF_c1tQjbmgea-8EoJNLYGW61VLoFaX0v296qjsjq3uu5xDnAYFHROB_JW4_Gk2d1Jn4cfTcp_tlx3rpl3KWpRDrZqVZ1KCUUlTmqKMWcE49uk8K6T3snwR1QuaV7Q-UOqBxoV1CVz4tX_51f8_D2949NESyOAi4tXwInV1x4Ih5CKqTcEMMHQq7eeVBhGahfPfOe8_9GLqMD93hY7DCYNAoQEdRfKPOSYQ</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Tong, Fang</creator><creator>Wu, Rongqi</creator><creator>Huang, Wen</creator><creator>Yang, Yi</creator><creator>Zhang, Lin</creator><creator>Zhang, Biao</creator><creator>Chen, Xin</creator><creator>Tang, Xiaohui</creator><creator>Zhou, Yiwu</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20170901</creationdate><title>Forensic Aspects of Homicides by Insulin Overdose</title><author>Tong, Fang ; Wu, Rongqi ; Huang, Wen ; Yang, Yi ; Zhang, Lin ; Zhang, Biao ; Chen, Xin ; Tang, Xiaohui ; Zhou, Yiwu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-edc4bd732cc6297e561365018ba15a839cc86ab6412400d823cf4fcb8b27bcbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipocytes</topic><topic>Adult</topic><topic>Aged, 80 and over</topic><topic>Astrocytes</topic><topic>Astrocytes - pathology</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Brain damage</topic><topic>Brain stem</topic><topic>Case-Control Studies</topic><topic>Cell Proliferation</topic><topic>Cerebellum</topic><topic>Cerebrum</topic><topic>Clinical medicine</topic><topic>Coma</topic><topic>Corpus callosum</topic><topic>Drug Overdose</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Forensic pathology</topic><topic>Forensic science</topic><topic>Forensic sciences</topic><topic>Gangrene</topic><topic>GFAP</topic><topic>Homicide</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - poisoning</topic><topic>Immunoassay</topic><topic>Immunofluorescence</topic><topic>Immunoglobulins</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Injection</topic><topic>Injections</topic><topic>Insulin</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - poisoning</topic><topic>Insulin overdose</topic><topic>Kidney - pathology</topic><topic>Liver - pathology</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardium - pathology</topic><topic>Overdose</topic><topic>Pathology</topic><topic>Peptides</topic><topic>Peripheral nerves</topic><topic>Protamine</topic><topic>Protamine sulfate</topic><topic>Protamines - metabolism</topic><topic>Skin</topic><topic>Skin - metabolism</topic><topic>Soft tissues</topic><topic>Statistical analysis</topic><topic>Substantia alba</topic><topic>Suicides & suicide attempts</topic><topic>Tissues</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tong, Fang</creatorcontrib><creatorcontrib>Wu, Rongqi</creatorcontrib><creatorcontrib>Huang, Wen</creatorcontrib><creatorcontrib>Yang, Yi</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Zhang, Biao</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Tang, Xiaohui</creatorcontrib><creatorcontrib>Zhou, Yiwu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Forensic science international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tong, Fang</au><au>Wu, Rongqi</au><au>Huang, Wen</au><au>Yang, Yi</au><au>Zhang, Lin</au><au>Zhang, Biao</au><au>Chen, Xin</au><au>Tang, Xiaohui</au><au>Zhou, Yiwu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Forensic Aspects of Homicides by Insulin Overdose</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>278</volume><spage>9</spage><epage>15</epage><pages>9-15</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><abstract>Highlights • This article is about research consisted of 4 actual homicidal insulin overdose cases. • In acute overdose, neuropathologic changes are not as typical as in previous hypoglycemic studies. • Severe reactive astrocyte proliferation with GFAP IHC is conspicuously found in brains of insulin overdose. • Presence of insulin and protamine at the injection sites is of forensic significance.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>28686962</pmid><doi>10.1016/j.forsciint.2017.06.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Adipocytes Adult Aged, 80 and over Astrocytes Astrocytes - pathology Autopsies Autopsy Brain Brain - pathology Brain damage Brain stem Case-Control Studies Cell Proliferation Cerebellum Cerebrum Clinical medicine Coma Corpus callosum Drug Overdose Female Fluorescent Antibody Technique Forensic pathology Forensic science Forensic sciences Gangrene GFAP Homicide Humans Hypoglycemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - poisoning Immunoassay Immunofluorescence Immunoglobulins Immunohistochemistry Inflammation Injection Injections Insulin Insulin - administration & dosage Insulin - poisoning Insulin overdose Kidney - pathology Liver - pathology Lung - pathology Male Middle Aged Myocardium - pathology Overdose Pathology Peptides Peripheral nerves Protamine Protamine sulfate Protamines - metabolism Skin Skin - metabolism Soft tissues Statistical analysis Substantia alba Suicides & suicide attempts Tissues Traumatic brain injury |
| title | Forensic Aspects of Homicides by Insulin Overdose |
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