The emerging landscape of circular RNA ciRS-7 in cancer (Review)

Circular RNAs (circRNAs) are a novel class of non-coding RNA molecules ubiquitously present in the cytoplasm of eukaryotic cells. CircRNAs are generated from exons or introns via multiple mechanisms. A recently identified circRNA, ciRS-7, can regulate the activities of miRNAs, mRNAs, and RBP to exer...

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Veröffentlicht in:	Oncology reports 2015-06, Vol.33 (6), p.2669-2674
Hauptverfasser:	PENG, LI, YUAN, XIAO QING, LI, GUAN CHENG
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biomarkers Breast cancer cancer Cancer therapies Carcinogenesis Carcinogenesis - genetics Cervical cancer ciRS-7 competing endogenous RNA Cytoplasm Gene expression Genetic aspects Genomes Health aspects Humans Liver cancer Medical prognosis MicroRNAs - genetics MicroRNAs - metabolism miR-7 miRNA sponge Mortality Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy RNA RNA - genetics RNA, Messenger - genetics Studies target genes Tumors
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Beschreibung
Zusammenfassung:	Circular RNAs (circRNAs) are a novel class of non-coding RNA molecules ubiquitously present in the cytoplasm of eukaryotic cells. CircRNAs are generated from exons or introns via multiple mechanisms. A recently identified circRNA, ciRS-7, can regulate the activities of miRNAs, mRNAs, and RBP to exert specific biological effects. Also, ciRS-7 acts as a natural competing endogenous RNA, a.k.a. 'super sponge' of microRNA-7 (miR-7) that sequesters and competitively inhibits the activity of miR-7. This competition between ciRS-7 and miR-7 may have profound effects on oncogenesis. This review will summarize the origin and functions of ciRS-7 and discuss the relationship among ciRS-7, its target molecules and cancer.
ISSN:	1021-335X 1791-2431
DOI:	10.3892/or.2015.3904