Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats

Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among these, vitamin A is important for a number of physiological activities. Vitamin A is absorbed by epithelial cells of the small intestine and is discharged into the lymphatic vessels as a component of chylomicrons and is d...

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Veröffentlicht in:International journal of molecular medicine 2015-03, Vol.35 (3), p.724-730
Hauptverfasser: HEBIGUCHI, TAKU, MEZAKI, YOSHIHIRO, MORII, MAYAKO, WATANABE, RYO, YOSHIKAWA, KIWAMU, MIURA, MITSUTAKA, IMAI, KATSUYUKI, SENOO, HARUKI, YOSHINO, HIROAKI
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container_title International journal of molecular medicine
container_volume 35
creator HEBIGUCHI, TAKU
MEZAKI, YOSHIHIRO
MORII, MAYAKO
WATANABE, RYO
YOSHIKAWA, KIWAMU
MIURA, MITSUTAKA
IMAI, KATSUYUKI
SENOO, HARUKI
YOSHINO, HIROAKI
description Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among these, vitamin A is important for a number of physiological activities. Vitamin A is absorbed by epithelial cells of the small intestine and is discharged into the lymphatic vessels as a component of chylomicrons and is delivered to the liver. In the present study, we used a rat model of SB syndrome in order to assess its effects on the expression of genes associated with the absorption, transport and metabolism of vitamin A. In the rats with SB, the intestinal mRNA expression levels of cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than those in the sham-operated rats, as shown by RT-qPCR. Immunohistochemical analysis revealed that absorptive epithelial cells stained positive for both CRBP II and lecithin retinol acyltransferase, which are both required for the effective esterification of vitamin A. In the rats with SB, the retinol content in the ileum and the retinyl ester content in the jejunum were lower than those in the sham-operated rats, as shown by quantitative analysis of retinol and retinyl esters by high performance liquid chromatography. These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A.
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subjects Animals
apolipoprotein A
Apolipoproteins
Apolipoproteins A - genetics
Apolipoproteins A - metabolism
Care and treatment
cellular retinol-binding protein II
Dehydrogenases
Disease Models, Animal
Fatty acids
Gene Expression Regulation
Genetic aspects
intestinal adaptation
Intestine, Small - metabolism
Intestine, Small - surgery
lecithin retinol acyltransferase
Liver - metabolism
Malabsorption syndromes
Physiological aspects
Protein Transport
Proteins
Rats
Retinol-Binding Proteins, Cellular - genetics
Retinol-Binding Proteins, Cellular - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Rodents
short bowel syndrome
Short Bowel Syndrome - genetics
Short Bowel Syndrome - metabolism
Small intestine
Surgery
Up-Regulation
Vitamin A
Vitamin A - metabolism
title Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats
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