Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats
Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among these, vitamin A is important for a number of physiological activities. Vitamin A is absorbed by epithelial cells of the small intestine and is discharged into the lymphatic vessels as a component of chylomicrons and is d...
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creator | HEBIGUCHI, TAKU MEZAKI, YOSHIHIRO MORII, MAYAKO WATANABE, RYO YOSHIKAWA, KIWAMU MIURA, MITSUTAKA IMAI, KATSUYUKI SENOO, HARUKI YOSHINO, HIROAKI |
description | Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among these, vitamin A is important for a number of physiological activities. Vitamin A is absorbed by epithelial cells of the small intestine and is discharged into the lymphatic vessels as a component of chylomicrons and is delivered to the liver. In the present study, we used a rat model of SB syndrome in order to assess its effects on the expression of genes associated with the absorption, transport and metabolism of vitamin A. In the rats with SB, the intestinal mRNA expression levels of cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than those in the sham-operated rats, as shown by RT-qPCR. Immunohistochemical analysis revealed that absorptive epithelial cells stained positive for both CRBP II and lecithin retinol acyltransferase, which are both required for the effective esterification of vitamin A. In the rats with SB, the retinol content in the ileum and the retinyl ester content in the jejunum were lower than those in the sham-operated rats, as shown by quantitative analysis of retinol and retinyl esters by high performance liquid chromatography. These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A. |
doi_str_mv | 10.3892/ijmm.2015.2066 |
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Among these, vitamin A is important for a number of physiological activities. Vitamin A is absorbed by epithelial cells of the small intestine and is discharged into the lymphatic vessels as a component of chylomicrons and is delivered to the liver. In the present study, we used a rat model of SB syndrome in order to assess its effects on the expression of genes associated with the absorption, transport and metabolism of vitamin A. In the rats with SB, the intestinal mRNA expression levels of cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than those in the sham-operated rats, as shown by RT-qPCR. Immunohistochemical analysis revealed that absorptive epithelial cells stained positive for both CRBP II and lecithin retinol acyltransferase, which are both required for the effective esterification of vitamin A. In the rats with SB, the retinol content in the ileum and the retinyl ester content in the jejunum were lower than those in the sham-operated rats, as shown by quantitative analysis of retinol and retinyl esters by high performance liquid chromatography. These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.2015.2066</identifier><identifier>PMID: 25585692</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Animals ; apolipoprotein A ; Apolipoproteins ; Apolipoproteins A - genetics ; Apolipoproteins A - metabolism ; Care and treatment ; cellular retinol-binding protein II ; Dehydrogenases ; Disease Models, Animal ; Fatty acids ; Gene Expression Regulation ; Genetic aspects ; intestinal adaptation ; Intestine, Small - metabolism ; Intestine, Small - surgery ; lecithin retinol acyltransferase ; Liver - metabolism ; Malabsorption syndromes ; Physiological aspects ; Protein Transport ; Proteins ; Rats ; Retinol-Binding Proteins, Cellular - genetics ; Retinol-Binding Proteins, Cellular - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; short bowel syndrome ; Short Bowel Syndrome - genetics ; Short Bowel Syndrome - metabolism ; Small intestine ; Surgery ; Up-Regulation ; Vitamin A ; Vitamin A - metabolism</subject><ispartof>International journal of molecular medicine, 2015-03, Vol.35 (3), p.724-730</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-c4c9b2b8f9d4cf0fdcb4190ebebe2e76fb06293eb14caa2938a6d80da3a593593</citedby><cites>FETCH-LOGICAL-c574t-c4c9b2b8f9d4cf0fdcb4190ebebe2e76fb06293eb14caa2938a6d80da3a593593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25585692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HEBIGUCHI, TAKU</creatorcontrib><creatorcontrib>MEZAKI, YOSHIHIRO</creatorcontrib><creatorcontrib>MORII, MAYAKO</creatorcontrib><creatorcontrib>WATANABE, RYO</creatorcontrib><creatorcontrib>YOSHIKAWA, KIWAMU</creatorcontrib><creatorcontrib>MIURA, MITSUTAKA</creatorcontrib><creatorcontrib>IMAI, KATSUYUKI</creatorcontrib><creatorcontrib>SENOO, HARUKI</creatorcontrib><creatorcontrib>YOSHINO, HIROAKI</creatorcontrib><title>Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among these, vitamin A is important for a number of physiological activities. Vitamin A is absorbed by epithelial cells of the small intestine and is discharged into the lymphatic vessels as a component of chylomicrons and is delivered to the liver. In the present study, we used a rat model of SB syndrome in order to assess its effects on the expression of genes associated with the absorption, transport and metabolism of vitamin A. In the rats with SB, the intestinal mRNA expression levels of cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than those in the sham-operated rats, as shown by RT-qPCR. Immunohistochemical analysis revealed that absorptive epithelial cells stained positive for both CRBP II and lecithin retinol acyltransferase, which are both required for the effective esterification of vitamin A. In the rats with SB, the retinol content in the ileum and the retinyl ester content in the jejunum were lower than those in the sham-operated rats, as shown by quantitative analysis of retinol and retinyl esters by high performance liquid chromatography. These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A.</description><subject>Animals</subject><subject>apolipoprotein A</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins A - genetics</subject><subject>Apolipoproteins A - metabolism</subject><subject>Care and treatment</subject><subject>cellular retinol-binding protein II</subject><subject>Dehydrogenases</subject><subject>Disease Models, Animal</subject><subject>Fatty acids</subject><subject>Gene Expression Regulation</subject><subject>Genetic aspects</subject><subject>intestinal adaptation</subject><subject>Intestine, Small - metabolism</subject><subject>Intestine, Small - surgery</subject><subject>lecithin retinol acyltransferase</subject><subject>Liver - metabolism</subject><subject>Malabsorption syndromes</subject><subject>Physiological aspects</subject><subject>Protein Transport</subject><subject>Proteins</subject><subject>Rats</subject><subject>Retinol-Binding Proteins, Cellular - genetics</subject><subject>Retinol-Binding Proteins, Cellular - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>short bowel syndrome</subject><subject>Short Bowel Syndrome - genetics</subject><subject>Short Bowel Syndrome - metabolism</subject><subject>Small intestine</subject><subject>Surgery</subject><subject>Up-Regulation</subject><subject>Vitamin A</subject><subject>Vitamin A - metabolism</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkU1v1DAQhiMEoqVw5YgsceHixbGdDx9XVaErFZAQIG6W40wWr5w42M4Cv61_jom2LQdkyzMaP_OheYviZck2olX8rTuM44azssKnrh8V52WjSsql_P4Y_ZI1VDRVfVY8S-nAGK-kap8WZ7yq2qpW_Ly4_WBSckcgXfgFnkRIYLMLE1nmCPvFmwyJ5B9A3IRedpPxZPz8cUvgNwKYiqiHI_hEwkAseI85EesgGjzt3NS7aU_mGDK4iex2xEw9MXPwbg730S3dfTvFfYb4X7-jy2ZcMZKyyUvCPxJNTs-LJ4PxCV7c2Yvi67urL5fX9ObT-93l9obaqpGZWmlVx7t2UL20Axt628lSMejwcGjqoWM1VwK6Ulpj0GtN3besN8JUSuC9KF6f6uK8PxecSh_CEnGypEsluJBV0_J_1N540G4aQo7Gji5ZvZVMcaFw60htTpSNIaUIg56jG038o0umV0X1qqheFdWropjw6q750o3QP-D3EiLw5gSkGVfo-pAemLUUFRVlgrKGS_EXr5Gudg</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>HEBIGUCHI, TAKU</creator><creator>MEZAKI, YOSHIHIRO</creator><creator>MORII, MAYAKO</creator><creator>WATANABE, RYO</creator><creator>YOSHIKAWA, KIWAMU</creator><creator>MIURA, MITSUTAKA</creator><creator>IMAI, KATSUYUKI</creator><creator>SENOO, HARUKI</creator><creator>YOSHINO, HIROAKI</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20150301</creationdate><title>Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats</title><author>HEBIGUCHI, TAKU ; MEZAKI, YOSHIHIRO ; MORII, MAYAKO ; WATANABE, RYO ; YOSHIKAWA, KIWAMU ; MIURA, MITSUTAKA ; IMAI, KATSUYUKI ; SENOO, HARUKI ; YOSHINO, HIROAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c574t-c4c9b2b8f9d4cf0fdcb4190ebebe2e76fb06293eb14caa2938a6d80da3a593593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>apolipoprotein A</topic><topic>Apolipoproteins</topic><topic>Apolipoproteins A - genetics</topic><topic>Apolipoproteins A - metabolism</topic><topic>Care and treatment</topic><topic>cellular retinol-binding protein II</topic><topic>Dehydrogenases</topic><topic>Disease Models, Animal</topic><topic>Fatty acids</topic><topic>Gene Expression Regulation</topic><topic>Genetic aspects</topic><topic>intestinal adaptation</topic><topic>Intestine, Small - metabolism</topic><topic>Intestine, Small - surgery</topic><topic>lecithin retinol acyltransferase</topic><topic>Liver - metabolism</topic><topic>Malabsorption syndromes</topic><topic>Physiological aspects</topic><topic>Protein Transport</topic><topic>Proteins</topic><topic>Rats</topic><topic>Retinol-Binding Proteins, Cellular - genetics</topic><topic>Retinol-Binding Proteins, Cellular - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>short bowel syndrome</topic><topic>Short Bowel Syndrome - genetics</topic><topic>Short Bowel Syndrome - metabolism</topic><topic>Small intestine</topic><topic>Surgery</topic><topic>Up-Regulation</topic><topic>Vitamin A</topic><topic>Vitamin A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HEBIGUCHI, TAKU</creatorcontrib><creatorcontrib>MEZAKI, YOSHIHIRO</creatorcontrib><creatorcontrib>MORII, MAYAKO</creatorcontrib><creatorcontrib>WATANABE, RYO</creatorcontrib><creatorcontrib>YOSHIKAWA, KIWAMU</creatorcontrib><creatorcontrib>MIURA, MITSUTAKA</creatorcontrib><creatorcontrib>IMAI, KATSUYUKI</creatorcontrib><creatorcontrib>SENOO, HARUKI</creatorcontrib><creatorcontrib>YOSHINO, HIROAKI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HEBIGUCHI, TAKU</au><au>MEZAKI, YOSHIHIRO</au><au>MORII, MAYAKO</au><au>WATANABE, RYO</au><au>YOSHIKAWA, KIWAMU</au><au>MIURA, MITSUTAKA</au><au>IMAI, KATSUYUKI</au><au>SENOO, HARUKI</au><au>YOSHINO, HIROAKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats</atitle><jtitle>International journal of molecular medicine</jtitle><addtitle>Int J Mol Med</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>35</volume><issue>3</issue><spage>724</spage><epage>730</epage><pages>724-730</pages><issn>1107-3756</issn><eissn>1791-244X</eissn><abstract>Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among these, vitamin A is important for a number of physiological activities. Vitamin A is absorbed by epithelial cells of the small intestine and is discharged into the lymphatic vessels as a component of chylomicrons and is delivered to the liver. In the present study, we used a rat model of SB syndrome in order to assess its effects on the expression of genes associated with the absorption, transport and metabolism of vitamin A. In the rats with SB, the intestinal mRNA expression levels of cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than those in the sham-operated rats, as shown by RT-qPCR. Immunohistochemical analysis revealed that absorptive epithelial cells stained positive for both CRBP II and lecithin retinol acyltransferase, which are both required for the effective esterification of vitamin A. In the rats with SB, the retinol content in the ileum and the retinyl ester content in the jejunum were lower than those in the sham-operated rats, as shown by quantitative analysis of retinol and retinyl esters by high performance liquid chromatography. These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>25585692</pmid><doi>10.3892/ijmm.2015.2066</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Animals apolipoprotein A Apolipoproteins Apolipoproteins A - genetics Apolipoproteins A - metabolism Care and treatment cellular retinol-binding protein II Dehydrogenases Disease Models, Animal Fatty acids Gene Expression Regulation Genetic aspects intestinal adaptation Intestine, Small - metabolism Intestine, Small - surgery lecithin retinol acyltransferase Liver - metabolism Malabsorption syndromes Physiological aspects Protein Transport Proteins Rats Retinol-Binding Proteins, Cellular - genetics Retinol-Binding Proteins, Cellular - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents short bowel syndrome Short Bowel Syndrome - genetics Short Bowel Syndrome - metabolism Small intestine Surgery Up-Regulation Vitamin A Vitamin A - metabolism |
title | Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats |
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