Effects of N-acetyl-glucosamine-coated glycodendrimers as biological modulators in the B16F10 melanoma model in vivo

According to new data in literature related to the above article (http://dx.doi.org./10.1016/j.imlet.2013.09.009; http://www.mdpi.com/1422-0067/15/1/1271) following a re-evaluation of controversial results of Professor K. Bezouska on NKR-P1 (rat and mouse receptors) interactions with carbohydrates,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of oncology 2014-04, Vol.44 (4), p.1410-1410
Hauptverfasser: VANNUCCI, LUCA, FISEROVÁ, ANNA, SADALAPURE, KASHINATH, LINDHORST, THISBE K, KULDOVÁ, MARKETA, ROSSMANN, PAVEL, HORVÁTH, ONDREJ, KREN, VLADIMIR, KRIST, PAVEL, BEZOUSKA, KAREL, LUPTOVCOVÁ, MARTINA, MOSCA, FRANCO, POSPÍSIL, MILOSLAV
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:According to new data in literature related to the above article (http://dx.doi.org./10.1016/j.imlet.2013.09.009; http://www.mdpi.com/1422-0067/15/1/1271) following a re-evaluation of controversial results of Professor K. Bezouska on NKR-P1 (rat and mouse receptors) interactions with carbohydrates, we need to correct some statements of this paper and the interpretation of some results consequent to these statements (which were based on published data by Professor K. Bezouska considered still valid at the time of preparation and publication of this paper). [...]the effects of PAMAM-GlcNAc8 reported in this paper, modulating the tumor biology and immune response, have to be re-interpreted: as the result of not exclusive interaction of glycodendrimers with NKR-P1 receptor and NK cells but as the possible result of interactions with a wider panel of cells and receptors of innate immunity to be better clarified (as already suggested at the end of the Discussion and in the conclusions of this paper).
ISSN:1019-6439
1791-2423
DOI:10.3892/ijo.2014.2288