Anti-allergic effects of a nonameric peptide isolated from the intestine gastrointestinal digests of abalone (Haliotis discus hannai) in activated HMC-1 human mast cells

The aim of the present study was to examine whether the intestine gastrointestinal (GI) digests of abalone [Haliotis discus hannai (H. discus hannai)] modulate inflammatory responses and to elucidate the mechanisms involved. The GI digests of the abalone intestines were fractionated into fractions I...

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Veröffentlicht in:	International journal of molecular medicine 2016-01, Vol.37 (1), p.243-250
Hauptverfasser:	KO, SEOK-CHUN, LEE, DAE-SUNG, PARK, WON SUN, YOO, JONG SU, YIM, MI-JIN, QIAN, ZHONG-JI, LEE, CHANG-MIN, OH, JUNGHWAN, JUNG, WON-KYO, CHOI, IL-WHAN
Format:	Artikel
Sprache:	eng
Schlagworte:	abalone Allergies Amino Acid Sequence Analysis Animals Anti-Allergic Agents - isolation & purification Anti-Allergic Agents - pharmacology Asthma Biological Products - isolation & purification Biological Products - pharmacology Cell Line Cell Survival - drug effects Cytokines Cytokines - immunology Disease Enzymes gastrointestinal digest Gastrointestinal Tract - chemistry Gastropoda - chemistry Haliotis discus hannai histamine Histamine Release - drug effects Humans Immunoglobulin E - immunology Inflammation Mediators - immunology Kinases Male Mast cells Mast Cells - cytology Mast Cells - drug effects Mast Cells - immunology Mice, Inbred ICR Mitogen-Activated Protein Kinases - immunology NF-kappa B - immunology Passive Cutaneous Anaphylaxis - drug effects Peptides Peptides - isolation & purification Peptides - pharmacology Phosphorylation pro-inflammatory cytokines Shellfish Tumor necrosis factor-TNF
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Zusammenfassung:	The aim of the present study was to examine whether the intestine gastrointestinal (GI) digests of abalone [Haliotis discus hannai (H. discus hannai)] modulate inflammatory responses and to elucidate the mechanisms involved. The GI digests of the abalone intestines were fractionated into fractions I (>10 kDa), II (5-10 kDa) and III (
ISSN:	1107-3756 1791-244X
DOI:	10.3892/ijmm.2015.2420