Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells

Tannic acid (TA), is a potent anti-oxidant, showing anti-proliferative effects on numerous cancers. The ability of TA to induce proliferation inhibition on the rare tumor, gingival squamous cell carcinoma (GSCC), comprising

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of oncology 2015-09, Vol.47 (3), p.1111-1120
Hauptverfasser:	DARVIN, PRAMOD, BAEG, SEUNG JO, JOUNG, YOUN HEE, SP, NIPIN, KANG, DONG YOUNG, BYUN, HYO JOO, PARK, JE UK, YANG, YOUNG MOK
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents - pharmacology Apoptosis Cancer Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Cell cycle Cell Cycle - drug effects Cell growth Cell Line, Tumor Cytochrome Drug therapy G1 arrest Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Gingival Neoplasms - drug therapy Gingival Neoplasms - metabolism Health aspects Humans Immunoglobulins intrinsic apoptosis Jak2/STAT3 Janus Kinase 2 - metabolism Kinases Metastasis Mitochondria Mitochondria - drug effects Mouth cancer Oral cancer p21Waf1/Cip1 Phosphorylation - drug effects Proteins Signal Transduction - drug effects STAT3 Transcription Factor - metabolism tannic acid Tannins Tannins - pharmacology
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Beschreibung
Zusammenfassung:	Tannic acid (TA), is a potent anti-oxidant, showing anti-proliferative effects on numerous cancers. The ability of TA to induce proliferation inhibition on the rare tumor, gingival squamous cell carcinoma (GSCC), comprising
ISSN:	1019-6439 1791-2423
DOI:	10.3892/ijo.2015.3098