Combined effects of M1 muscarinic acetylcholine receptor agonist TBPB and [alpha]7n-acetylcholine receptor activator GTS-21 on mouse mortality and blood concentration of proinflammatory cytokines in sepsis

Combined effects of M1 muscarinic acetylcholine receptor agonist TBPB and [alpha]7n-acetylcholine receptor activator GTS-21 on mouse mortality and blood concentration of proinflammatory cytokines in sepsis

Experiments on random-bred albino mice showed that M1 muscarinic acetylcholine receptor agonist (TBPB) and [alpha]7n-acetylcholine receptor agonist (GTS-21) significantly reduced mortality of mice with experimental sepsis (intraperitoneally administration of E. coli) in 4 and 24 h after modeling by...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bulletin of experimental biology and medicine 2017-04, Vol.162 (6), p.750
Hauptverfasser: Zabrodskii, P.F, Gromov, M.S, Maslyakov, V.V
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine receptors (muscarinic)
Animal experimentation
Blood levels
Crystallization
Cytokines
Health aspects
Infection
Inflammation
Interleukin 1
Interleukin 6
Microbial drug resistance
Mortality
Rodents
Sepsis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Experiments on random-bred albino mice showed that M1 muscarinic acetylcholine receptor agonist (TBPB) and [alpha]7n-acetylcholine receptor agonist (GTS-21) significantly reduced mortality of mice with experimental sepsis (intraperitoneally administration of E. coli) in 4 and 24 h after modeling by reducing blood concentration of proinflammatory cytokines TNF-[alpha], IL-1[beta], and IL-6. Combined treatment with TBPB and GTS-21 determined their additive effect. Key Words: cholinergic anti-inflammatory pathway; proinflammatory cytokines; sepsis; Ml-acetylcholine receptors; a7n-acetylcholine receptors
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3704-3