Ruthenium‐Catalyzed, Keto‐Directed, Site‐Selective C–H Activation of Diverse Chromanones with Alkenes

A simple and versatile approach towards the synthesis of highly functionalized C5‐alkenylated chromanones in good yields in a regio‐ and stereoselective fashion was explored. This reaction takes place through chelation‐aided oxidative coupling of keto‐directed, site‐selective C–H activation by using chromanones with alkenes in the presence of a ruthenium catalyst under mild conditions. A protocol for the synthesis of C5‐olefinated 2‐arylchromanones in a regio‐ and stereoselective fashion through the ruthenium‐catalyzed oxidative coupling of diversified 2‐arylchromanones with various alkenes through a keto‐directed, site‐selective C–H activation reaction is developed. IBO = isobornyl.