Synthesis of novel macrocyclic Schiff's‐base and its complexes having N2O2 group of donor atoms. Characterization and anticancer screening are studied

Novel Schiff base [N′,N′″‐(((ethane‐1,2‐diylbis(oxy))bis(2,1‐phenylene))bis(methanylylidene))di(benzohydrazide)] was formed by the condensation reaction of benzohydrazide with 2,2′‐(ethane‐1,2‐diylbis(oxy))dibenzaldehyde. Its reaction with various metal ions was studied and the structures of the new products were characterized using common analytical and spectroscopic methods. All the metal complexes have pronounced anticancer activities. The antimicrobial activities against Gram‐negative and Gram‐positive bacteria were investigated. A novel Schiff base and its conformational changes on complexation with various transition metal ions have been studied. The antimicrobial activity of the compounds was studied against Gram‐negative and Gram‐positive bacteria. Anticancer screening studies were performed using human colorectal cancer (HCT), hepatic cancer (HepG2) and breast cancer (MCF‐7) cell lines.