A New Approach to Enhance Bioavailability: Dosage Forms with Extended Residence Time in the Stomach

[...]of stomach contractions after eating, the content in the stomach transforms into small particles and turns into a form of suspension. [...]despite all these studies, the values expected in in vivo studies could not be obtained. 2.Floating Dosage Systems a- Singe-unit systems: Because of the residence time in the stomach shows variation, these systems have low reliability and reproducibility (Agrawal et al., 2005). [...]it was found that by using calcium silicate and by changing the hydroxypropyl cellulose / ethyl cellulose ratio, controlled release floating granules with desired features could be obtained. [...]of its contact with the gastric liquid, the dosage form, which is small at the beginning, swells, enabling it to reside in the stomach for an extended period of time (Hoffman et al., 2003).