A21 IMMUNE MECHANISMS OF SARCOIDOSIS AND OTHER GRANULOMATOUS DISEASES: Race Distinct Gene Expression Patterns In Peripheral Blood Mononuclear Cells And Bronchoalveolar Lavage Cells Of Sarcoidosis Subjects

A21 IMMUNE MECHANISMS OF SARCOIDOSIS AND OTHER GRANULOMATOUS DISEASES: Race Distinct Gene Expression Patterns In Peripheral Blood Mononuclear Cells And Bronchoalveolar Lavage Cells Of Sarcoidosis Subjects

Results: 147 and 45 paired PBMC and BAL cell samples, from black and white subjects, respectively, passed data quality control, and were included in the analysis. 76 and 417 genes were increased, 113 and 541 genes were decreased in BAL and PBMC, respectively in black compared to white subjects. 55 o...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Vukmirovic, M, Yan, X, Gulati, M, Drake, W P, Gibson, K F, Deluliis, G, Woolard, T, Adams, T, Hu, B, Aurelien, N, O'Neal, S, Becich, M, Hochheiser, H, Senior, R M, Herzog, E L, Chen, E S, Morris, A M, Leader, J K, Zhang, Y, Garcia, J G N, Wisniewski, S R, Benos, P V, Maier, L A, Moller, D R, Koth, L L, Kaminski, N
Format: Artikel
Sprache:eng
Schlagworte:
Cell cycle
Disease
Gene expression
Metabolism
Sarcoidosis
T cell receptors
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Zusammenfassung:Results: 147 and 45 paired PBMC and BAL cell samples, from black and white subjects, respectively, passed data quality control, and were included in the analysis. 76 and 417 genes were increased, 113 and 541 genes were decreased in BAL and PBMC, respectively in black compared to white subjects. 55 of the race related genes overlapped between PBMC and BAL. Other pathways increased in PBMC from black subjects included T cell receptor, CD28, MHCI immune response, and cell cycle pathways.
ISSN:1073-449X
1535-4970