A71 ONCOGENES AND ANGIOGENESIS IN LUNG TUMORS: Tumor-Suppressive Microrna-218 Inhibits Cancer Cell Migration And Invasion Directly Targeting Tpd52 In Lung Squamous Cell Carcinoma

A71 ONCOGENES AND ANGIOGENESIS IN LUNG TUMORS: Tumor-Suppressive Microrna-218 Inhibits Cancer Cell Migration And Invasion Directly Targeting Tpd52 In Lung Squamous Cell Carcinoma

Molecular targeted therapies have had little benefit in the management of lung squamous cell carcinoma (lung-SCC). [...]new treatment options based on current genomic approaches are needed for lung-SCC. Through combination of in silico analysis and gene expression data searching, tumor protein D52 (...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Kumamoto, T, Seki, N, Mataki, H, Kamikawaji, K, Takagi, K, Suetsugu, T, Watanabe, M, Mizuno, K, Samukawa, T, Inoue, H
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Cell adhesion & migration
Gene expression
Lung cancer
MicroRNAs
Squamous cell carcinoma
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Zusammenfassung:Molecular targeted therapies have had little benefit in the management of lung squamous cell carcinoma (lung-SCC). [...]new treatment options based on current genomic approaches are needed for lung-SCC. Through combination of in silico analysis and gene expression data searching, tumor protein D52 (TPD52) was selected as a putative target of miR-218. [...]direct binding of miR-218 to the 3'-UTR of TPD52 was observed by dual luciferase reporter assay.
ISSN:1073-449X
1535-4970