A72 MECHANISMS DRIVING FIBROSIS: Lactate Dehydrogenase Expression And Activity Is Altered In Alveolar Type Ii Cells From Patients With Idiopathic Pulmonary Fibrosis

A72 MECHANISMS DRIVING FIBROSIS: Lactate Dehydrogenase Expression And Activity Is Altered In Alveolar Type Ii Cells From Patients With Idiopathic Pulmonary Fibrosis

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating, chronic and progressive disease characterized by extensive lung scarring and eventual loss of pulmonary function. Methods: Human and murine primary ATII cells from normal or fibrotic lungs (IPF patients or bleomycin-treated mice) were...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Newton, D A, Lottes, R G, Paintlia, M K, Ryan, R M, Baatz, J E
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Sprache:eng
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Dehydrogenases
Lungs
Metabolism
Pulmonary fibrosis
Rodents
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container_title American journal of respiratory and critical care medicine
container_volume 195
creator Newton, D A
Lottes, R G
Paintlia, M K
Ryan, R M
Baatz, J E
description Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating, chronic and progressive disease characterized by extensive lung scarring and eventual loss of pulmonary function. Methods: Human and murine primary ATII cells from normal or fibrotic lungs (IPF patients or bleomycin-treated mice) were purified and analyzed for lactate dehydrogenase (LDH) expression (mRNA by qPCR; protein by non-denaturing gel electrophoresis) and activity (extracellular flux and biochemical assays).
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source Journals@Ovid Ovid Autoload; American Thoracic Society (ATS) Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Dehydrogenases
Lungs
Metabolism
Pulmonary fibrosis
Rodents
title A72 MECHANISMS DRIVING FIBROSIS: Lactate Dehydrogenase Expression And Activity Is Altered In Alveolar Type Ii Cells From Patients With Idiopathic Pulmonary Fibrosis
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