C73 NEW MECHANISMS AND THERAPIES IN COPD: A Comprehensive Evaluation Of Primary Alveolar Type Ii Epithelial Cell Models Amenable To Drug Discovery

C73 NEW MECHANISMS AND THERAPIES IN COPD: A Comprehensive Evaluation Of Primary Alveolar Type Ii Epithelial Cell Models Amenable To Drug Discovery

At shorter time points, ATII cells cultured in 384 well plates and at Air-Liquid interface (ALI) demonstrated similar functional responses and gene expression profiles. [...]the 2D transwell and ALI models offer suitable systems for assessing long term phenotypic responses of ATII cells in vitro.

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Bibliographische Detailangaben
Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Bauer, C M T, Daya, S, Mwase, C, Kobari, S, Feldman, K, Dowling, M
Format: Artikel
Sprache:eng
Schlagworte:
Chronic obstructive pulmonary disease
Gene expression
Genotype & phenotype
Homeostasis
Surfactants
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Zusammenfassung:At shorter time points, ATII cells cultured in 384 well plates and at Air-Liquid interface (ALI) demonstrated similar functional responses and gene expression profiles. [...]the 2D transwell and ALI models offer suitable systems for assessing long term phenotypic responses of ATII cells in vitro.
ISSN:1073-449X
1535-4970