D21 IMMUNE PATHWAYS IN ACUTE LUNG INJURY AND FIBROSIS: Role Of Dendritic Cells In Pulmonary Fibrosis In Mice

Methods The following mouse models were employed: 1) FMS-like tyrosine kinase-3 ligand (Flt3L) KO mice exhibiting congenital deficiency of Flt3L. 2) Chimeric zDC+/DTR mice allowing selective depletion of dendritic cells while sparing macrophages. 3) CD103 KO mice lacking the aE chain (CD103) of ß7 integrin. [...]CD103 deficiency did not impact on lung fibrosis after AdTGF-ß1 exposure relative to WT mice.