D105 CRITICAL CARE: FROM CELL TO MICE TO BEDSIDE - TRANSLATIONAL STUDIES IN SEPSIS AND PNEUMONIA: Delivery Of Human Msc Derived Extracellular Vesicles Directly To The Lung Improves Bacterial Pneumonia Acute Lung Injury

Human mesenchymal stromal cells (hMSC) have been shown to reduce the severity of bacterial pneumonia induced acute respiratory distress syndrome in the Rat (1). A lower dose of 100ug extracellular vesicles delivered by intra-tracheal instillation was also efficacious in the animal model; animal survival was enhanced and the decrement in arterial oxygen pressure was significantly reduced compared to PBS vehicle control animals (Figure 1).