A72 MECHANISMS DRIVING FIBROSIS: Fibronectin Is Modified By O,o'-Dityrosine Cross-Linking: Implications For Idiopathic Pulmonary Fibrosis

A72 MECHANISMS DRIVING FIBROSIS: Fibronectin Is Modified By O,o'-Dityrosine Cross-Linking: Implications For Idiopathic Pulmonary Fibrosis

[...]we tested the hypothesis that fibronectin, a tyrosine-rich extracellular matrix protein, is modified by o,o'-dityrosine cross-linking and is increased in plasma of IPF patients. Fibronectin was modified by o,o'-dityrosine cross-linking in human patients, a mouse model, and in in vitro...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Locy, M, Rangarajan, S, Kurundkar, A, Chanda, D, de Andrade, J A, Pennathur, S, Thannickal, V J
Format: Artikel
Sprache:eng
Schlagworte:
Fibroblasts
Plasma
Proteins
Pulmonary fibrosis
Rodents
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Zusammenfassung:[...]we tested the hypothesis that fibronectin, a tyrosine-rich extracellular matrix protein, is modified by o,o'-dityrosine cross-linking and is increased in plasma of IPF patients. Fibronectin was modified by o,o'-dityrosine cross-linking in human patients, a mouse model, and in in vitro systems utilizing human lung fibroblasts.
ISSN:1073-449X
1535-4970