D110 CELLULAR AND MOLECULAR INVESTIGATIONS IN THORACIC ONCOLOGY: Mcc950 A Novel Inhibitor Of Nlrp3 Inflammasome Reduces Migration And Invasion Of Lung Adenocarcinoma In-Vitro

D110 CELLULAR AND MOLECULAR INVESTIGATIONS IN THORACIC ONCOLOGY: Mcc950 A Novel Inhibitor Of Nlrp3 Inflammasome Reduces Migration And Invasion Of Lung Adenocarcinoma In-Vitro

Recently an increased expression of NLRP3 was demonstrated among A549 cell line (lung adenocarcinoma) possibly contributing to its metastatic aggressive behavior. NLRP3 levels did not differ between the groups most likely due to the fact that MCC950 inhibits only NLRP3 activation and not its basal e...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Siterman, M, Lengier, S, Zadik, L, Ofir, N, Nachmias, N, Rotem, M, Yadgar, M, Schwarz, Y, Bar-Shai, A
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Lung cancer
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Recently an increased expression of NLRP3 was demonstrated among A549 cell line (lung adenocarcinoma) possibly contributing to its metastatic aggressive behavior. NLRP3 levels did not differ between the groups most likely due to the fact that MCC950 inhibits only NLRP3 activation and not its basal expression in lung cancer cell, which is known to be constitutively high in A549.
ISSN:1073-449X
1535-4970