C78 FIBROSIS: MEDIATORS AND MODULATORS: Preclinical Efficacy Of The Dual Growth Factor Antagonist Brivanib In Models Of Lung Fibrosis

C78 FIBROSIS: MEDIATORS AND MODULATORS: Preclinical Efficacy Of The Dual Growth Factor Antagonist Brivanib In Models Of Lung Fibrosis

[...]in vivo efficacy in a standard bleomycin lung fibrosis model was investigated. FGF induced receptor phosphorylation in normal human lung fibroblasts (NHLF) is inhibited with an IC50 of ~150 nM whereas the proliferation IC50 is ~1000 nM.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Kitson, C, Mauricio, M, Fuentes, H, Kowalik, M, Azzara, A, Dierks, E, Robl, J, Fuentes, M, Ellsworth, B
Format: Artikel
Sprache:eng
Schlagworte:
Fibroblasts
Kinases
Permeability
Phosphorylation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:[...]in vivo efficacy in a standard bleomycin lung fibrosis model was investigated. FGF induced receptor phosphorylation in normal human lung fibroblasts (NHLF) is inhibited with an IC50 of ~150 nM whereas the proliferation IC50 is ~1000 nM.
ISSN:1073-449X
1535-4970