C35 ASTHMA AND ALLERGY CELLULAR INVESTIGATIONS: Modulation Of Hyaluronan Deposition And Leukocyte Adhesion By Nitric Oxide

C35 ASTHMA AND ALLERGY CELLULAR INVESTIGATIONS: Modulation Of Hyaluronan Deposition And Leukocyte Adhesion By Nitric Oxide

Corresponding author's email: majorsa@ccf.org RATIONALE Alterations of the extracellular matrix, including changes in hyaluronan (HA), play an important role in the pathogenesis of asthma but little is known about the factors that modulate its deposition or the potential consequences. Taken tog...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Majors, A, Chakravarti, R, Stuehr, D, Ruple, L, Erzurum, S, Janocha, A J, Aronica, M
Format: Artikel
Sprache:eng
Schlagworte:
Asthma
Cables
Inflammation
Nitric oxide
Rodents
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Zusammenfassung:Corresponding author's email: majorsa@ccf.org RATIONALE Alterations of the extracellular matrix, including changes in hyaluronan (HA), play an important role in the pathogenesis of asthma but little is known about the factors that modulate its deposition or the potential consequences. Taken together, NO-induced production of leukocyte-binding HA by SMCs provides a new potential mechanism for airway inflammation in asthma and suggests an important role of non-immune cells in promoting the chronic inflammation.
ISSN:1073-449X
1535-4970