A31 MECHANISMS IN CYSTIC FIBROSIS AND OTHER BRONCHIECTATIC DISEASES: Neutrophil Elastase And Ceramide: Impact On Cystic Fibrosis Lung Inflammation
Altered ceramide metabolism is associated with increased lung inflammation, and has been reported in cystic fibrosis transmembrane conductance regulator (CFTR)-deficient mice and in respiratory epithelia of CF patients. [...]using samples stored in the VCU Sputum Biorepository, we tested sputum from...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2017-01, Vol.195 |
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| container_title | American journal of respiratory and critical care medicine |
| container_volume | 195 |
| creator | Karandashova, S Kummarapurugu, A B Zheng, S Rubin, B K Voynow, J |
| description | Altered ceramide metabolism is associated with increased lung inflammation, and has been reported in cystic fibrosis transmembrane conductance regulator (CFTR)-deficient mice and in respiratory epithelia of CF patients. [...]using samples stored in the VCU Sputum Biorepository, we tested sputum from CF patients to determine whether ceramide concentrations determined by HPLC-ESI-MS/MS correlated with sputum NE activity determined by spectrophotometric assay. |
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| ispartof | American journal of respiratory and critical care medicine, 2017-01, Vol.195 |
| issn | 1073-449X 1535-4970 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Cystic fibrosis Inflammation Lung diseases Lungs Neutrophils Proteins Rodents |
| title | A31 MECHANISMS IN CYSTIC FIBROSIS AND OTHER BRONCHIECTATIC DISEASES: Neutrophil Elastase And Ceramide: Impact On Cystic Fibrosis Lung Inflammation |
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