A31 MECHANISMS IN CYSTIC FIBROSIS AND OTHER BRONCHIECTATIC DISEASES: Neutrophil Elastase And Ceramide: Impact On Cystic Fibrosis Lung Inflammation

A31 MECHANISMS IN CYSTIC FIBROSIS AND OTHER BRONCHIECTATIC DISEASES: Neutrophil Elastase And Ceramide: Impact On Cystic Fibrosis Lung Inflammation

Altered ceramide metabolism is associated with increased lung inflammation, and has been reported in cystic fibrosis transmembrane conductance regulator (CFTR)-deficient mice and in respiratory epithelia of CF patients. [...]using samples stored in the VCU Sputum Biorepository, we tested sputum from...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Karandashova, S, Kummarapurugu, A B, Zheng, S, Rubin, B K, Voynow, J
Format: Artikel
Sprache:eng
Schlagworte:
Cystic fibrosis
Inflammation
Lung diseases
Lungs
Neutrophils
Proteins
Rodents
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Zusammenfassung:Altered ceramide metabolism is associated with increased lung inflammation, and has been reported in cystic fibrosis transmembrane conductance regulator (CFTR)-deficient mice and in respiratory epithelia of CF patients. [...]using samples stored in the VCU Sputum Biorepository, we tested sputum from CF patients to determine whether ceramide concentrations determined by HPLC-ESI-MS/MS correlated with sputum NE activity determined by spectrophotometric assay.
ISSN:1073-449X
1535-4970