A61 TUBERCULOSIS DISEASE: HOST RESPONSE AND DIAGNOSTICS: Measurement Of Interferon-Gamma (ifn-γ) And Ifn-γ-Inducible Protein 10 (ip-10) In Combination On Pleural Fluid As An Alternative To Adenosine Deaminase For Diagnosis Of Tuberculosis

Corresponding author's email: pneumo.uerj@gmail.com Background: The production of inflammatory mediators by immune cells upon Mycobacterium tuberculosis (Mtb) antigens stimulation is enlarged at the site of infection. [...]immunoassays based on Mtb-specific response should be excellent tools in the search for biomarkers in different specimens and may be useful for tuberculosis' diagnosis on its various clinical presentations, such as Pleural TB (PlTB). [...]the combined use of IFN-y and IP-10 increased sensitivity in comparison to ADA alone (92% vs. 87.5%). [...]IFN-y and IP-10 (Nil) measurement in PF showed excellent correlation with ADA (K=0.83, 95% Cl 0.66-0.99, K=0.70, 95% Cl 0.49-0, 90, respectively).