C21 OMICS IN LUNG DISEASE: Whole Genome Sequencing Study On Bronchodilator Drug Response In Ethnically Diverse Children With Asthma

C21 OMICS IN LUNG DISEASE: Whole Genome Sequencing Study On Bronchodilator Drug Response In Ethnically Diverse Children With Asthma

Despite significant racial/ethnic variation in bronchodilator drug response (BDR), albuterol is often the only medication prescribed for asthma, regardless of disease severity. Methods We performed whole genome sequencing on 1,500 ethnically diversed children with asthma from the extremes of broncho...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Mak, A, White, M J, Szpiech, Z A, Eckalbar, W, Pino-Yanes, M, Oh, S, Hu, D, Huntsman, S, Eng, C, Davis, A, Serebrisky, D, Brigino-Buenaventura, E, Lurmann, F, Farber, H J, Rodriguez-Santana, J R, Meade, K, Borrell, L N, LeNoir, M A, Avila, P C, Kumar, R, Sen, S, Thyne, S, Rodriguez-Cintron, W, Kwok, P-Y, Torgerson, D G, Galanter, J, Ahituv, N, Ziv, E, Seibold, M A, Zaitlen, N, Hernandez, R D, Burchard, E G
Format: Artikel
Sprache:eng
Schlagworte:
Asthma
Bronchodilators
Genomes
Population
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Zusammenfassung:Despite significant racial/ethnic variation in bronchodilator drug response (BDR), albuterol is often the only medication prescribed for asthma, regardless of disease severity. Methods We performed whole genome sequencing on 1,500 ethnically diversed children with asthma from the extremes of bronchodilator drug response to albuterol.
ISSN:1073-449X
1535-4970