D97 IMPACT OF INFLAMMATION ON ACUTE LUNG INJURY: Being A Good Influence? Alveolar Type 2 Cells Dampen Macrophage Inflammatory Response In Acute Lung Injury Via Glycolysis Driven Mechanism

D97 IMPACT OF INFLAMMATION ON ACUTE LUNG INJURY: Being A Good Influence? Alveolar Type 2 Cells Dampen Macrophage Inflammatory Response In Acute Lung Injury Via Glycolysis Driven Mechanism

Introduction Loss of type II airway epithelial cells (ATII) is a key pathologic feature of acute lung injury (ALI), a clinical syndrome responsible for high mortality and significant morbidity. Shifting glucose metabolism away from glycolysis either with a chemical inhibitor or with genetic knock do...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Roy, R, El Kasmi, K C, Burns, N, Eltzschig, H, Stenmark, K R, Vohwinkel, C
Format: Artikel
Sprache:eng
Schlagworte:
Gene expression
Inflammation
Metabolism
Rodents
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Zusammenfassung:Introduction Loss of type II airway epithelial cells (ATII) is a key pathologic feature of acute lung injury (ALI), a clinical syndrome responsible for high mortality and significant morbidity. Shifting glucose metabolism away from glycolysis either with a chemical inhibitor or with genetic knock down altered the ability of epithelial cells to inhibit macrophage responsiveness to LPS.
ISSN:1073-449X
1535-4970