C77 ADVANCEMENTS IN THE BIOLOGY OF BPD AND OTHER CONGENITAL PEDIATRIC LUNG DISEASES: Gene Regulatory Roles For Lysyl Oxidases In Lung Fibroblasts

Lysyl oxidases are copper-dependent amine oxidases historically regarded as extracellular matrix (ECM) remodeling enzymes, with documented roles in lung development, bronchopulmonary dysplasia (BPD), lung cancer, pulmonary hypertension, and lung fibrosis. Recent evidence suggests that lysyl oxidases also have physiological functions that are not related to the ECM, and have been identified as components of transcription factor complexes. [...]we explored a role for lysyl oxidases as transcriptional regulators in primary mouse lung fibroblasts, the key fibrogenic cell-type of the lung.