A24 IPF: CLINICAL STUDIES, THERAPEUTICS, AND MORE I: Lung Mechanics And The Gastroesophageal Junction In Patients With Pulmonary Fibrosis And Gastroesophageal Reflux

A24 IPF: CLINICAL STUDIES, THERAPEUTICS, AND MORE I: Lung Mechanics And The Gastroesophageal Junction In Patients With Pulmonary Fibrosis And Gastroesophageal Reflux

When the cohort was divided between those with and without GERD, subjects with GERD had a higher respiratory rate (24.7 vs 21.9; p = 0.05), lower resting LES pressure (30.3 vs 44.9; p < 0.001), lower crural diaphragm pressure at end inspiration (38.5 vs 58.5; p < 0.001), and higher prevalence...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Gaeckle, N, Suri, J, Midani, D, Orthey, P, Parkman, H, Schey, R, Smith, M S, Criner, G J
Format: Artikel
Sprache:eng
Schlagworte:
Esophagus
Gastroesophageal reflux
Hernias
Mechanics
Pulmonary fibrosis
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Zusammenfassung:When the cohort was divided between those with and without GERD, subjects with GERD had a higher respiratory rate (24.7 vs 21.9; p = 0.05), lower resting LES pressure (30.3 vs 44.9; p < 0.001), lower crural diaphragm pressure at end inspiration (38.5 vs 58.5; p < 0.001), and higher prevalence of hiatal hernia (65.0% vs 39.2%; p = 0.02). Conclusion: Pulmonary fibrosis subjects with GERD have a lower resting LES pressure, weaker crural diaphragm contraction, and increased prevalence of hiatal hernia than those without GERD.
ISSN:1073-449X
1535-4970