C75 FIBROSIS: CURRENT AND FUTURE APPROACHES: Alveolar Epithelial Cell Endoplasmic Reticulum Stress Impairs Antiviral Immunity In The Lung

Rationale: Endoplasmic reticulum (ER) stress is common in alveolar epithelial cells (AECs) in lungs from patients with idiopathic pulmonary fibrosis (IPF). At 2 weeks post-infection, L188Q SFTPC mice had increased total and lytic virus in the lung, along with more total inflammatory cells and increased levels of interferon gamma, although T-cell subsets were similar between groups.