D97 IMPACT OF INFLAMMATION ON ACUTE LUNG INJURY: Uptake Of Cell-Free Hemoglobin Impairs Cytokine Production By Macrophages

D97 IMPACT OF INFLAMMATION ON ACUTE LUNG INJURY: Uptake Of Cell-Free Hemoglobin Impairs Cytokine Production By Macrophages

Rationale: Cell-free hemoglobin (CFH) is elevated in the airspace during acute lung injury and is associated with increased inflammation. Preliminary data showing that supplemental haptoglobin improves CFH uptake suggests that haptoglobin could be a novel therapy for attenuation of acute lung injury...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Shaver, C M, Landstreet, S R, Putz, N, Hubler, M J, Hasty, A H, Ware, L B, Bastarache, J A
Format: Artikel
Sprache:eng
Schlagworte:
Cytokines
Inflammation
Microscopy
Rodents
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Zusammenfassung:Rationale: Cell-free hemoglobin (CFH) is elevated in the airspace during acute lung injury and is associated with increased inflammation. Preliminary data showing that supplemental haptoglobin improves CFH uptake suggests that haptoglobin could be a novel therapy for attenuation of acute lung injury.
ISSN:1073-449X
1535-4970