D105 CRITICAL CARE: FROM CELL TO MICE TO BEDSIDE - TRANSLATIONAL STUDIES IN SEPSIS AND PNEUMONIA: Cell-Free Hemoglobin Augments Acute Kidney Injury In A Sepsis Mouse Model

D105 CRITICAL CARE: FROM CELL TO MICE TO BEDSIDE - TRANSLATIONAL STUDIES IN SEPSIS AND PNEUMONIA: Cell-Free Hemoglobin Augments Acute Kidney Injury In A Sepsis Mouse Model

In a model of polymicrobial sepsis, intravenous injection of CFH to mimic the high circulating levels in human sepsis significantly augments AKI as measured by AKI biomarkers and oxidative mitochondrial DNA damage in the kidney. TL1TR000447 from the National Center for Advancing Translational Scienc...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Paul, M, Kuck, J, Shaver, C M, Putz, N, De Caestecker, M P, Bastarache, J A, Ware, L B
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Deoxyribonucleic acid
DNA
Gene expression
Kidneys
Sepsis
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Zusammenfassung:In a model of polymicrobial sepsis, intravenous injection of CFH to mimic the high circulating levels in human sepsis significantly augments AKI as measured by AKI biomarkers and oxidative mitochondrial DNA damage in the kidney. TL1TR000447 from the National Center for Advancing Translational Sciences, as well as Award No. 3R01HL126671-03S1 from the National Heart, Lung, and Blood Institute of the National Institutes of Health to MP, HL103836 to LBW, HL126671 to JAB and a Vanderbilt Faculty Research Scholars award to CMS.
ISSN:1073-449X
1535-4970