D109 UNDERSTANDING THE MECHANISMS OF ACUTE LUNG INJURY: Regulation Of Lung Endothelial Permeability And Inflammatory Responses By Prostaglandin A2: Role Of Ep4 Receptor

D109 UNDERSTANDING THE MECHANISMS OF ACUTE LUNG INJURY: Regulation Of Lung Endothelial Permeability And Inflammatory Responses By Prostaglandin A2: Role Of Ep4 Receptor

PGA2 also suppressed LPS-induced inflammatory signaling by inhibiting NFkB pathway and expression of EC adhesion molecules ICAM1, VCAM1. In vivo, PGA2 was protective in two distinct models of acute lung injury (ALI): LPS-induced inflammatory injury and two-hit ALI caused by suboptimal mechanical ven...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Shah, A, Sarich, N, Tian, Y, Ke, Y, Meliton, A Y, Birukova, A, Birukov, K
Format: Artikel
Sprache:eng
Schlagworte:
Kinases
Permeability
Rodents
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Zusammenfassung:PGA2 also suppressed LPS-induced inflammatory signaling by inhibiting NFkB pathway and expression of EC adhesion molecules ICAM1, VCAM1. In vivo, PGA2 was protective in two distinct models of acute lung injury (ALI): LPS-induced inflammatory injury and two-hit ALI caused by suboptimal mechanical ventilation and injection of thrombin receptor activating peptide (TRAP).
ISSN:1073-449X
1535-4970