C73 NEW MECHANISMS AND THERAPIES IN COPD: Smad3 And P38 Pathways Mediate Cigarette Smoke-Induced Decreases In Cftr And Bk Channel Activities Leading To Mucociliary Dysfunction

C73 NEW MECHANISMS AND THERAPIES IN COPD: Smad3 And P38 Pathways Mediate Cigarette Smoke-Induced Decreases In Cftr And Bk Channel Activities Leading To Mucociliary Dysfunction

While activation of apically expressed sodium channels (ENac) reduce ASL volume, activation of cystic fibrosis transmembrane conductance regulator (CFTR) channels, calcium-activated chloride channels (CaCC) and/or potassium channels (BK) channels increase water availability and thereby increasing AS...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Sailland-Tschudi, J, Grosche, A, Baumlin-Schmid, N, Dennis, J, Schmid, A, Krick, S, Salathe, M
Format: Artikel
Sprache:eng
Schlagworte:
Chronic obstructive pulmonary disease
Cigarettes
Kinases
Phosphorylation
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Zusammenfassung:While activation of apically expressed sodium channels (ENac) reduce ASL volume, activation of cystic fibrosis transmembrane conductance regulator (CFTR) channels, calcium-activated chloride channels (CaCC) and/or potassium channels (BK) channels increase water availability and thereby increasing ASL volume. [...]phosphorylation of Smad3 and p38 was shown in smokers and patients with COPD.
ISSN:1073-449X
1535-4970