A21 IMMUNE MECHANISMS OF SARCOIDOSIS AND OTHER GRANULOMATOUS DISEASES: The Roles Of Monocyte Subsets In Pulmonary Sarcoidosis: Phenotypic And Transcriptomic Analysis

A21 IMMUNE MECHANISMS OF SARCOIDOSIS AND OTHER GRANULOMATOUS DISEASES: The Roles Of Monocyte Subsets In Pulmonary Sarcoidosis: Phenotypic And Transcriptomic Analysis

Differential gene expression analyses revealed significantly more genes up- or down-regulated in the non-classical subset compared to the classical subset, and the least number of gene expression changes in classical monocytes. [...]in GSEA analyses to date, we found an over-enrichment of genes in p...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Machiraju, S N, Benn, B S, Bhakta, N R, Lehman, Z E, Arger, N, Koth, L L
Format: Artikel
Sprache:eng
Schlagworte:
Gene expression
Inflammation
Sarcoidosis
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Zusammenfassung:Differential gene expression analyses revealed significantly more genes up- or down-regulated in the non-classical subset compared to the classical subset, and the least number of gene expression changes in classical monocytes. [...]in GSEA analyses to date, we found an over-enrichment of genes in pathways involved in microbial pathogen detection and innate immune response in the classical monocyte subset in sarcoidosis samples compared to control samples.
ISSN:1073-449X
1535-4970