A35 SEVERE ASTHMA: Differential Responses To Systemic Corticosteroids As Assessed By Cluster Analysis Of Data From The Severe Asthma Research Program (sarp)

A35 SEVERE ASTHMA: Differential Responses To Systemic Corticosteroids As Assessed By Cluster Analysis Of Data From The Severe Asthma Research Program (sarp)

Methods: 23 clinical, physiologic and inflammatory variables from 218 adult asthmatic subjects with paired (pre and 2-3 weeks post triamcinolone 40 mg IM) sputum gene expression samples from patients in SARP3 were analyzed. [...]Cluster 4 (46 subjects) was characterized by the largest lung function...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Wu, W, Bleecker, E R, Meyers, D A, Moore, W C, Israel, E, Fitzpatrick, A, Sorkness, R L, Peters, M, Kerr, S, Hastie, A T, Wenzel, S E
Format: Artikel
Sprache:eng
Schlagworte:
Asthma
Cluster analysis
Gene expression
Neutrophils
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Zusammenfassung:Methods: 23 clinical, physiologic and inflammatory variables from 218 adult asthmatic subjects with paired (pre and 2-3 weeks post triamcinolone 40 mg IM) sputum gene expression samples from patients in SARP3 were analyzed. [...]Cluster 4 (46 subjects) was characterized by the largest lung function decrease post CS and the largest increase in sputum neutrophils, without change in sputum eosinophils, FeNO or ACQ6.
ISSN:1073-449X
1535-4970