A27 BRONCHIECTASIS AND LUNG INFECTION: Respiratory Syncytial Virus Infection Alters The Human Fetal Neuroprogenitor Cell Fate And Survival

A27 BRONCHIECTASIS AND LUNG INFECTION: Respiratory Syncytial Virus Infection Alters The Human Fetal Neuroprogenitor Cell Fate And Survival

RSV also affected stem cells and substance P-expressing neuronal protein levels by reducing the expression of SOX2 and substance P at day 1 followed by a 2-band truncation at day 3 and a loss of the high molecular weight band later on. Gene expression analyses showed a down regulation of GFAP in inf...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Belkadi, A, Rezaee, F, Harford, T J, Bokun, V, Sophie, L, Piedimonte, G
Format: Artikel
Sprache:eng
Schlagworte:
Gene expression
Infections
Proteins
Respiratory syncytial virus
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Zusammenfassung:RSV also affected stem cells and substance P-expressing neuronal protein levels by reducing the expression of SOX2 and substance P at day 1 followed by a 2-band truncation at day 3 and a loss of the high molecular weight band later on. Gene expression analyses showed a down regulation of GFAP in infected cells and an up-regulation of SOX2 gene at day 1 post-infection, which was followed by a down-regulation at day 3.
ISSN:1073-449X
1535-4970