A72 MECHANISMS DRIVING FIBROSIS: Inhibition Of Lactate Dehydrogenase Prevents Radiation-Induced Pulmonary Fibrosis

Corresponding author's email: jennifer_judge@urmc.rochester.edu Exposure of the lung to ionizing radiation such as in radiation therapy for tumors of the lung, breast and lymph node can result in pulmonary fibrosis. Lung tissue sections were trichrome stained for collagen, and stained for for а-smooth muscle actin (myofibroblast marker), active TGF-ß, and HIF-1a by immunohistochemistry.