C107 MITOCHONDRIA AND METABOLIC ALTERATIONS IN LUNG DISEASE: Using Metabolomics To Define Ards Endotypes
After obtaining informed consent, serum samples were collected from septic (severe sepsis or septic shock) ventilated patients with ARDS (from 2009 - 2014), from patients with pneumonia who progressed to ARDS (from 2009 - 2014) and from ventilated ICU control patients during the same time period and...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2017-01, Vol.195 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Winston, B Donnelly, S Banoei, M Metwaly, S Mourad, A Vogel, H |
| description | After obtaining informed consent, serum samples were collected from septic (severe sepsis or septic shock) ventilated patients with ARDS (from 2009 - 2014), from patients with pneumonia who progressed to ARDS (from 2009 - 2014) and from ventilated ICU control patients during the same time period and stored in CCEPTR, an ICU tissue bank. 96 sepsis-induced (indirect lung injury) ARDS patients and 56 pneumonia-induced (direct lung injury) ARDS were identified and compared. The PLS-DA data comparing these three groups reveals a model with an R2 = 0.66, Q2 = 0.44, p = 1.977 x 10-35. [...]NMR metabolomics data analysis reveals good ARDS endotype separation. |
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[...]NMR metabolomics data analysis reveals good ARDS endotype separation.</description><subject>Data analysis</subject><subject>Discriminant analysis</subject><subject>Intensive care</subject><subject>Metabolism</subject><subject>Nitric oxide</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pneumonia</subject><subject>Sepsis</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNik8LgjAcQEcU9Pc7_KCzsKVmdlu6aqATckI3sVpllCtnh759HvoAnd6D9zpoQFzbtRzfw93WsWdbjuPv-2hozA1jMlsQPEDXoC0Qc5kE20SEO06BihBiJukqiXgANJJsRyVPRApcQJSJDYQ8ZTRlS8hMWV0gVk1x0Hf9KI8GpIZQnctKAa1PBlh10s3nqcwY9c7F3ajJjyM0XTMZbK1nrV9vZZr8pt911aac-LO5Rxa-Tez_ri8-QkKP</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Winston, B</creator><creator>Donnelly, S</creator><creator>Banoei, M</creator><creator>Metwaly, S</creator><creator>Mourad, A</creator><creator>Vogel, H</creator><general>American Thoracic Society</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170101</creationdate><title>C107 MITOCHONDRIA AND METABOLIC ALTERATIONS IN LUNG DISEASE: Using Metabolomics To Define Ards Endotypes</title><author>Winston, B ; 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| ispartof | American journal of respiratory and critical care medicine, 2017-01, Vol.195 |
| issn | 1073-449X 1535-4970 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Data analysis Discriminant analysis Intensive care Metabolism Nitric oxide NMR Nuclear magnetic resonance Pneumonia Sepsis |
| title | C107 MITOCHONDRIA AND METABOLIC ALTERATIONS IN LUNG DISEASE: Using Metabolomics To Define Ards Endotypes |
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