A31 MECHANISMS IN CYSTIC FIBROSIS AND OTHER BRONCHIECTATIC DISEASES: Reduced Hvcn1 In Neutrophils Of Individuals With Cystic Fibrosis Alters Phagosomal Ph And Degranulation

Rationale Cystic fibrosis (CF) is an inherited genetic condition resulting in a higher frequency of airway infections, causing irreversible damage to the lung and eventual respiratory failure. HVCN1 knockout murine studies have demonstrated increased neutrophil phagosomal pH, significantly higher primary granule degranulation and reduced neutrophil mediated bacterial killing.