A98 SEEING IS BELIEVING: USING NOVEL IMAGING TECHNIQUES TO UNDERSTAND THE LUNG IN HEALTH AND DISEASE: Ventilation Defect Percent In Helium-3 Mri Is Associated With Severe Outcomes In Asthma

Rationale: Hyperpolarized helium-3 magnetic resonance imaging (HP 3He MRI) provides regional measurements of airway obstruction, potentially enhancing sensitivity to clinical outcomes in asthma. Receiver operating characteristic (ROC) analysis and statistical associations were used to evaluate a suite of biomarkers as classifiers of emergency department (ED) visits and hospitalizations, including VDP, eosinophils, neutrophils, and monocytes/macrophages in blood and sputum, forced expiratory volume in one second (FEV1) percent predicted (PP), FEV1 divided by forced vital capacity (FVC) PP, relative area under -856 Hounsfield units (RA-856) on CT, and residual volume divided by total lung capacity (RV/TLC).