A72 MECHANISMS DRIVING FIBROSIS: Syndecan-2 Inhibits Myofibroblast Differentiation In Tgf-β1-Stimulated Fibroblasts Through Receptor Type Protein Tyrosine Phosphatase Eta Activation

A72 MECHANISMS DRIVING FIBROSIS: Syndecan-2 Inhibits Myofibroblast Differentiation In Tgf-β1-Stimulated Fibroblasts Through Receptor Type Protein Tyrosine Phosphatase Eta Activation

Recently, our group demonstrated that Syndecan-2 (SDC2) is potent antifibrotic protein in bleomycin-induced pulmonary fibrosis by inhibiting TGF-ß signaling and lung epithelial cell death. [...]the role of SDC2 in fibroblast activation during fibrosis is still unknown. [...]this study is focused on...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: Tsoyi, K, Poli, S, Doyle, T, El-Chemali, S, Konishi, K, Chu, S G, Perrella, M, Rosas, I O
Format: Artikel
Sprache:eng
Schlagworte:
Fibroblasts
Phosphatase
Proteins
Pulmonary fibrosis
Rodents
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Zusammenfassung:Recently, our group demonstrated that Syndecan-2 (SDC2) is potent antifibrotic protein in bleomycin-induced pulmonary fibrosis by inhibiting TGF-ß signaling and lung epithelial cell death. [...]the role of SDC2 in fibroblast activation during fibrosis is still unknown. [...]this study is focused on the understanding the role of SDC2 in fibroblast activation and myofibroblast differentiation and the importance of receptor type protein tyrosine phosphatase n (PTPRJ/CD148/DEP-1, endogenous receptor for SDC2), in SDC2 mediated effect.
ISSN:1073-449X
1535-4970