D104 ADVANCES IN INTERSTITIAL LUNG DISEASE: High Attenuation Areas On Chest CT And Clinical Respiratory Outcomes In Community-Dwelling Adults: The Multi-Ethnic Study Of Atherosclerosis (MESA)

Rationale: We previously showed that an increased percentage of high attenuation areas (HAA) in CT lung fields is associated with biomarkers of lung inflammation and extracellular matrix remodeling, reduced lung function, increased risk of interstitial lung abnormalities, and all-cause mortality in community-dwelling adults, suggesting that HAA can detect subclinical interstitial lung disease (ILD). Methods: We measured HAA (percentage of imaged lung with attenuation between -600 and -250 HU) on baseline cardiac CT scans of participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort study that enrolled 6814 adults ages 45-84 in 2000-2002.