C28 FROM TARGETS TO THERAPIES IN FIBROSIS: Activated Human T Lymphocytes Inhibit Tgfβ-Induced Fibroblast To Myofibroblast Differentiation Via Prostaglandins E2 And D2

Co-culture supernatants contained anti-fibrotic prostaglandins E2 and D2, and the inhibitory effect of T-cells on myofibroblast differentiation was largely reversed when prostaglandin production was abrogated either by resting the T-cells prior to co-culture, or by treating co-cultures with pharmacological inhibitors of prostaglandin synthesis. [...]recent gene expression profiling of peripheral blood mononuclear cells in IPF patients showed that decreased expression of genes associated with T-cell activation was significantly associated with reduced transplant-free survival.