D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Pro-Inflammatory Priming Of Peripheral Blood Monocytes And Monocyte-Derived Macrophages From Calves With Hypoxic Pulmonary Hypertension
While MDMs from hypoxic animals already displayed higher LDH and HK levels at baseline, this was further enhanced upon stimulation with PH-Fib conditioned media, which was also seen for the expression of VEGFa, a HIF1 target gene. [...]when PBMCs were exposed to PH-Fib conditioned media, transcripti...
Gespeichert in:
| Veröffentlicht in: | American journal of respiratory and critical care medicine 2017-01, Vol.195 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | American journal of respiratory and critical care medicine |
| container_volume | 195 |
| creator | El Kasmi, K C Riddle, S Ostaff, M J Frid, M Flockton, A Stenmark, K R |
| description | While MDMs from hypoxic animals already displayed higher LDH and HK levels at baseline, this was further enhanced upon stimulation with PH-Fib conditioned media, which was also seen for the expression of VEGFa, a HIF1 target gene. [...]when PBMCs were exposed to PH-Fib conditioned media, transcription of IL1b was increased in PBMCs from hypoxic relative to those from normoxic calves. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1926716665</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1926716665</sourcerecordid><originalsourceid>FETCH-proquest_journals_19267166653</originalsourceid><addsrcrecordid>eNqNjc1ugkAUhUnTJrU_73CTrjGACLW7EVEm4S8CWldmYkfFwFw6gCmv2qfpLJp029U59ztfcm-0kTmdTHV75hq3qhvuRLft2fu99tC2F8MwrVfTGGnfC8sFClsSxwTmPuySYg3j8RjiZOOHEPleQGKa5dQDGmd0FeQq8wTSIoySmKx3sCGZV4RkDQua-STz3yCVqFNxrFhdsw7loEBZl-IEyRFSLsvmzCWrYF4hfkCEAg9Dx1sg4u_SF8q7cgXYQWJzZiclLCXW4LHqqvq27M4QDA1-lQdI-6pGwdQnRbjsuGhLFE_a3ZFVLX_-zUftZennXqA3Ej973nb7C_ZSqGlvzizHNR3HmU7-Z_0AmPFrPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1926716665</pqid></control><display><type>article</type><title>D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Pro-Inflammatory Priming Of Peripheral Blood Monocytes And Monocyte-Derived Macrophages From Calves With Hypoxic Pulmonary Hypertension</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><source>American Thoracic Society (ATS) Journals Online</source><source>Alma/SFX Local Collection</source><creator>El Kasmi, K C ; Riddle, S ; Ostaff, M J ; Frid, M ; Flockton, A ; Stenmark, K R</creator><creatorcontrib>El Kasmi, K C ; Riddle, S ; Ostaff, M J ; Frid, M ; Flockton, A ; Stenmark, K R</creatorcontrib><description>While MDMs from hypoxic animals already displayed higher LDH and HK levels at baseline, this was further enhanced upon stimulation with PH-Fib conditioned media, which was also seen for the expression of VEGFa, a HIF1 target gene. [...]when PBMCs were exposed to PH-Fib conditioned media, transcription of IL1b was increased in PBMCs from hypoxic relative to those from normoxic calves.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><language>eng</language><publisher>New York: American Thoracic Society</publisher><subject>Animals ; Fibroblasts ; Gene expression ; Hypoxia ; Pulmonary hypertension</subject><ispartof>American journal of respiratory and critical care medicine, 2017-01, Vol.195</ispartof><rights>Copyright American Thoracic Society 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>El Kasmi, K C</creatorcontrib><creatorcontrib>Riddle, S</creatorcontrib><creatorcontrib>Ostaff, M J</creatorcontrib><creatorcontrib>Frid, M</creatorcontrib><creatorcontrib>Flockton, A</creatorcontrib><creatorcontrib>Stenmark, K R</creatorcontrib><title>D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Pro-Inflammatory Priming Of Peripheral Blood Monocytes And Monocyte-Derived Macrophages From Calves With Hypoxic Pulmonary Hypertension</title><title>American journal of respiratory and critical care medicine</title><description>While MDMs from hypoxic animals already displayed higher LDH and HK levels at baseline, this was further enhanced upon stimulation with PH-Fib conditioned media, which was also seen for the expression of VEGFa, a HIF1 target gene. [...]when PBMCs were exposed to PH-Fib conditioned media, transcription of IL1b was increased in PBMCs from hypoxic relative to those from normoxic calves.</description><subject>Animals</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Hypoxia</subject><subject>Pulmonary hypertension</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNjc1ugkAUhUnTJrU_73CTrjGACLW7EVEm4S8CWldmYkfFwFw6gCmv2qfpLJp029U59ztfcm-0kTmdTHV75hq3qhvuRLft2fu99tC2F8MwrVfTGGnfC8sFClsSxwTmPuySYg3j8RjiZOOHEPleQGKa5dQDGmd0FeQq8wTSIoySmKx3sCGZV4RkDQua-STz3yCVqFNxrFhdsw7loEBZl-IEyRFSLsvmzCWrYF4hfkCEAg9Dx1sg4u_SF8q7cgXYQWJzZiclLCXW4LHqqvq27M4QDA1-lQdI-6pGwdQnRbjsuGhLFE_a3ZFVLX_-zUftZennXqA3Ej973nb7C_ZSqGlvzizHNR3HmU7-Z_0AmPFrPw</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>El Kasmi, K C</creator><creator>Riddle, S</creator><creator>Ostaff, M J</creator><creator>Frid, M</creator><creator>Flockton, A</creator><creator>Stenmark, K R</creator><general>American Thoracic Society</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170101</creationdate><title>D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Pro-Inflammatory Priming Of Peripheral Blood Monocytes And Monocyte-Derived Macrophages From Calves With Hypoxic Pulmonary Hypertension</title><author>El Kasmi, K C ; Riddle, S ; Ostaff, M J ; Frid, M ; Flockton, A ; Stenmark, K R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_19267166653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Fibroblasts</topic><topic>Gene expression</topic><topic>Hypoxia</topic><topic>Pulmonary hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Kasmi, K C</creatorcontrib><creatorcontrib>Riddle, S</creatorcontrib><creatorcontrib>Ostaff, M J</creatorcontrib><creatorcontrib>Frid, M</creatorcontrib><creatorcontrib>Flockton, A</creatorcontrib><creatorcontrib>Stenmark, K R</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Kasmi, K C</au><au>Riddle, S</au><au>Ostaff, M J</au><au>Frid, M</au><au>Flockton, A</au><au>Stenmark, K R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Pro-Inflammatory Priming Of Peripheral Blood Monocytes And Monocyte-Derived Macrophages From Calves With Hypoxic Pulmonary Hypertension</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><date>2017-01-01</date><risdate>2017</risdate><volume>195</volume><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>While MDMs from hypoxic animals already displayed higher LDH and HK levels at baseline, this was further enhanced upon stimulation with PH-Fib conditioned media, which was also seen for the expression of VEGFa, a HIF1 target gene. [...]when PBMCs were exposed to PH-Fib conditioned media, transcription of IL1b was increased in PBMCs from hypoxic relative to those from normoxic calves.</abstract><cop>New York</cop><pub>American Thoracic Society</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2017-01, Vol.195 |
| issn | 1073-449X 1535-4970 |
| language | eng |
| recordid | cdi_proquest_journals_1926716665 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Animals Fibroblasts Gene expression Hypoxia Pulmonary hypertension |
| title | D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Pro-Inflammatory Priming Of Peripheral Blood Monocytes And Monocyte-Derived Macrophages From Calves With Hypoxic Pulmonary Hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T23%3A09%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=D27%20I%20WANNA%20BE%20YOUR%20...%20NOVEL%20MECHANISTIC%20INSIGHT%20INTO%20PULMONARY%20VASCULAR%20DISEASE:%20Pro-Inflammatory%20Priming%20Of%20Peripheral%20Blood%20Monocytes%20And%20Monocyte-Derived%20Macrophages%20From%20Calves%20With%20Hypoxic%20Pulmonary%20Hypertension&rft.jtitle=American%20journal%20of%20respiratory%20and%20critical%20care%20medicine&rft.au=El%20Kasmi,%20K%20C&rft.date=2017-01-01&rft.volume=195&rft.issn=1073-449X&rft.eissn=1535-4970&rft_id=info:doi/&rft_dat=%3Cproquest%3E1926716665%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1926716665&rft_id=info:pmid/&rfr_iscdi=true |