D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Pro-Inflammatory Priming Of Peripheral Blood Monocytes And Monocyte-Derived Macrophages From Calves With Hypoxic Pulmonary Hypertension

D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Pro-Inflammatory Priming Of Peripheral Blood Monocytes And Monocyte-Derived Macrophages From Calves With Hypoxic Pulmonary Hypertension

While MDMs from hypoxic animals already displayed higher LDH and HK levels at baseline, this was further enhanced upon stimulation with PH-Fib conditioned media, which was also seen for the expression of VEGFa, a HIF1 target gene. [...]when PBMCs were exposed to PH-Fib conditioned media, transcripti...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Hauptverfasser: El Kasmi, K C, Riddle, S, Ostaff, M J, Frid, M, Flockton, A, Stenmark, K R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Fibroblasts
Gene expression
Hypoxia
Pulmonary hypertension
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Zusammenfassung:While MDMs from hypoxic animals already displayed higher LDH and HK levels at baseline, this was further enhanced upon stimulation with PH-Fib conditioned media, which was also seen for the expression of VEGFa, a HIF1 target gene. [...]when PBMCs were exposed to PH-Fib conditioned media, transcription of IL1b was increased in PBMCs from hypoxic relative to those from normoxic calves.
ISSN:1073-449X
1535-4970